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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10714 | CCR5 antagonist 1 | HIV Protease , CCR | |
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication. | |||
T71665 | INCB-9471 | HIV Protease , CCR | |
INCB-9471 is a CCR5 antagonist with anti-HIV activity and inhibits the interaction between HIV-1 gp120. | |||
T7499 | TAK-779 | Takeda 779 | HIV Protease , CXCR , CCR |
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3). | |||
T6016 | Maraviroc | Celsentri,UK-427857,Selzentry | HIV Protease , CCR |
Maraviroc (Selzentry) is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-1 entry via CCR5 coreceptor interaction. | |||
TQ0297 | Cenicriviroc | TAK-652,TBR-652 | HIV Protease , CCR |
Cenicriviroc (TAK-652) is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory activity. | |||
T3435 | Vicriviroc maleate | SCH-D (maleate),SCH-417690 (maleate) | HIV Protease , CCR |
Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in clinical development for the treatment... | |||
T2375 | BX471 | BX 471,BX-471,ZK-811752 | CCR |
BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist. | |||
T23770 | B07 hydrochloride | B 07 HCl,B-07 HCl,B-07 hydrochloride,B07 HCl,B 07 hydrochloride | |
B07 hydrochloride is a CCR5 antagonist-based inhibitor of HIV-1 entry. | |||
T28171 | Nifeviroc | TD-0232,TD 0232,TD0232 | |
Nifeviroc, a CCR5 antagonist, is used potentially for treatment of inflammatory responses to HIV type-1 infection. | |||
T14845 | BX471 hydrochloride | ZK-811752 hydrochloride | Others |
BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist (Ki: 1 nM for human CCR1). It shows 250-fold selectivity for CCR1 over CCR2, CCR5, and CXCR4. | |||
T28381 | PF-232798 | PF-00232798,PF 00232798,PF00232798 | |
PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity. | |||
T69582 | AMD-3451 free base | ||
AMD-3451 free base is a dual CCR5/CXCR4 antagonist which may be useful in the treatment of a wide variety of R5, R5/X4, and X4 strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2. AMD3451 is the first low-mo... | |||
T10756 | Cenicriviroc Mesylate | TBR-652 Mesylate,TAK-652 Mesylate | CCR |
Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity. | |||
T76567 | Met-RANTES (human) | ||
Met-RANTES (human), a partial antagonist of CCR5, diminishes the infiltration of blood monocytes into the liver [1]. | |||
T14208 | AMD 3465 | GENZ-644494 | HIV Protease |
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mA... |